Daclizumab: Development, Clinical Trials, and Practical Aspects of Use in Multiple Sclerosis
نویسندگان
چکیده
منابع مشابه
Daclizumab use in patients with pediatric multiple sclerosis.
BACKGROUND Daclizumab, a humanized monoclonal antibody specific for the interleukin 2 receptor α chain, reduces clinical and magnetic resonance imaging disease activity in patients with adult-onset multiple sclerosis (MS) as monotherapy or add-on therapy with interferon. OBJECTIVE To report the use of daclizumab in pediatric-onset MS. DESIGN Case series. SETTING Two comprehensive pediatri...
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Multiple sclerosis affects every part of the neuraxis and has replaced syphilis as the great mimicker in neurology. In this article, the author describes the entire spectrum of multiple sclerosis signs and symptoms, focal and diffuse brain lesions, look-alike diseases, the overactive immune response, the complex pathology of demyelination, death and dysfunction of oligodendroglia and neurons, M...
متن کاملclinical and epidemiological aspects of multiple sclerosis in children
abstract objective: according to the previous studies, 2-5 percent of patients with multiple sclerosis experienced the first episode of disease before the age 16. since the age of onset among children is not similar to that in general population, clinicians often fail to early diagnose the disease. this study aims to determine the epidemiological and clinical patterns of ms among iranian child...
متن کاملDaclizumab (anti-CD25) in multiple sclerosis.
Multiple sclerosis (MS) is a typical CD4 T cell-mediated autoimmune disease of the central nervous system (CNS) that leads to inflammation, demyelination, axonal damage, glial scarring and a broad range of neurological deficits. While disease-modifying drugs with a good safety profile and moderate efficacy have been available for 20 years now, a growing number of substances with superior therap...
متن کاملClinical and Epidemiological Aspects of Multiple Sclerosis in Children
OBJECTIVE Overall, 2%-5% of patients with multiple sclerosis (MS) experienced the first episode of disease before the age 18 years old. Since the age of onset among children is not similar to that in general population, clinicians often fail to early diagnose the disease. This study aimed to determine the epidemiological and clinical patterns of MS among Iranian children. MATERIALS & METHODS ...
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ژورنال
عنوان ژورنال: Neurotherapeutics
سال: 2017
ISSN: 1933-7213,1878-7479
DOI: 10.1007/s13311-017-0553-8